Below you will find scientific publications authored by our members or those enabled by our platform services.
2018
Bourque, Guillaume; Burns, Kathleen H; Gehring, Mary; Gorbunova, Vera; Seluanov, Andrei; Hammell, Molly; Imbeault, Michaël; Izsvák, Zsuzsanna; Levin, Henry L; Macfarlan, Todd S; Mager, Dixie L; Feschotte, Cédric
Ten things you should know about transposable elements Journal Article
In: Genome Biology, vol. 19, no. 1, pp. 199, 2018, ISSN: 1474-760X.
Abstract | Links | BibTeX | Tags: Aicardi-Goutieres Syndrome, Endogenous Retroviruses (ERV), Human Endogenous Retroviruses (HERVs), Syncytin, transposable elements
@article{bourque_ten_2018,
title = {Ten things you should know about transposable elements},
author = {Guillaume Bourque and Kathleen H Burns and Mary Gehring and Vera Gorbunova and Andrei Seluanov and Molly Hammell and Michaël Imbeault and Zsuzsanna Izsvák and Henry L Levin and Todd S Macfarlan and Dixie L Mager and Cédric Feschotte},
url = {https://doi.org/10.1186/s13059-018-1577-z},
doi = {10.1186/s13059-018-1577-z},
issn = {1474-760X},
year = {2018},
date = {2018-01-01},
urldate = {2021-05-19},
journal = {Genome Biology},
volume = {19},
number = {1},
pages = {199},
abstract = {Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.},
keywords = {Aicardi-Goutieres Syndrome, Endogenous Retroviruses (ERV), Human Endogenous Retroviruses (HERVs), Syncytin, transposable elements},
pubstate = {published},
tppubtype = {article}
}
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.