The SecureData4Health (SD4H) website is LIVE! SecureData4Health (SD4H) launched its new website. SecureData4Health (SD4H) is a secure cloud infrastructure aimed at providing high-throughput technologies for easy and secure genomic health data sharing and advanced analytics to maximize scientific discovery. Visit now: sd4health.ca Published: January 28, 2022
Gene fusion meta-calling with MetaFusion The Toronto Node of C3G has developed MetaFusion, a flexible meta-calling tool that amalgamates outputs from any number of fusion callers. Designed to overcome inconsistencies among frequently used fusion callers, MetaFusion is among the first ensemble fusion calling tools currently available. Individual results from [Read more]
Working with Genomics Coming From a Pure Software Engineering Background by Sebastian Ballesteros A little bit about my background While pursuing a Bachelor of Science in Software Engineering at McGill University, I joined the Canadian Centre for Computational Genomics as an intern in 2020. I started working at the [Read more]
Adapting to remote and electronic means of patient care Electronic and remote means of healthcare have become a staple over the past year, and the Toronto Node of C3G has been involved in several efforts to facilitate and improve remote patient care. In a joint effort with Smart Cancer [Read more]
Understanding why persons living with HIV are at increased risk of tuberculosis Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is often the result of a recent infection with Mycobacterium tuberculosis (Mtb) followed by rapid progression to the disease. Alveolar macrophages (AM) are the first cells [Read more]
Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19 Host genetic factors related to COVID-19 susceptibility and outcomes are of great interest, as their identification could elucidate the mechanisms of SARS-CoV-2 infection and severity, thereby providing clues about potential therapeutic targets. A recent [Read more]
Anesthesia-related Tweets during COVID-19 Twitter has become a social media nexus for the sharing of information, and in an Anesthesia & Analgesia Journal article published in April 2021, members of C3G’s Toronto Node at SickKids examined the way Twitter was used to share anesthesia-related information during the COVID-19 pandemic. [Read more]
Whole Genome STR Analysis By David Lougheed About Short Tandem Repeats In early 2021, Jeffrey Hyacinthe, another student here in Guillaume Bourque’s lab, wrote about repetitive sequences, focusing on transposable elements (TEs). Here I will discuss another type of repetitive sequence: short tandem repeats (STRs), also known as microsatellites. These [Read more]
New study analyzes different mechanisms in the establishment of sex-phenotype dependent methylation in mouse livers By Hector Galvez and Qinwei Zhuang AlOgayil, N., Bauermeister, K., Galvez, J.H. et al. Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver. [Read more]
How do jumping genes contribute to human diversity? by Clement Goubert In recognition of Transposons Day 2021 (June 16th), let’s take a look at the importance of active mobile genomic elements (once called “junk DNA”) to human health and diseases. Illustration: ANDRZEJ KRAUZE We are hosts to genomic hitchhikers Of the three [Read more]
