Making New Discoveries Using Public Data by Audrey Baguette Every research project is composed of three key elements: a question to answer, the analyzes to perform and the data to use. Often, that last component is limiting. Indeed, producing new data is expensive and sometimes even time-consuming. Thankfully, a solution [Read more]
Disambiguating mixed-species of graft samples by Senthilkumar Kailasam As a Bioinformatician, often I get to work with PDX cancer samples. I’ve recently been reading about samples containing genome admixture, and was revisiting strategies that we commonly use for analyzing these biological data. Presented here is a summary of the existing [Read more]
The ANCHOR pipeline by Emmanuel Gonzalez ANCHOR is a high-resolution metagenomics pipeline, the result of a multi-disciplinary collaboration between C3G and researchers at Institut de recherche en biologie végétale (IRBV) at Université de Montreal. Published in 2019 in the journal Environmental Microbiology, the pipeline demonstrated unprecedented accuracy in its [Read more]
Infant Glioma: Characterizing the landscape of genetic drivers and their clinical impact Recently published in [Nature Communications ], this paper presents work by members of the C3G Toronto node that integrates genomic and transcriptomic analyses to assess the molecular and clinical features of infant glioma patients. Examining single nucleotide [Read more]
Altered microbiome composition in individuals with fibromyalgia This summer has also been very special for C3G’s metagenome specialist Emmanuel Gonzalez with a publication in Pain highlighting a strong potential link between the microbiome and fibromyalgia, a terrible and elusive disorder affecting a large fraction of the population. This study drew quite [Read more]
GSoC 2019 is over! Again this year, C3G was a Google Summer of Code organization. For people unfamiliar with it, GSoC is in Google’s own words: ” a global program that matches students up with open source, free software and technology-related organizations to write code and get paid to [Read more]
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease Another noteworthy publication to which C3G members contributed as authors was published in Nature Immunology this summer. An important focus of the study was the comparison of HIV-specific CD4 T-cells subpopulations from patients who have undergone [Read more]
Methylation signatures investigations The C3G Toronto node has also been involved in two projects to investigate methylation signatures for specific conditions. We have recently published a manuscript in BMC Medical Genomics in which we describe specific DNA methylation signatures for Nicolaides-Baraitser syndrome (NBS), a rare childhood condition that affects [Read more]
GenPipes: an open-source framework for distributed and scalable genomic analyses It started in June with the publication of our beloved GenPipes framework and set of NGS data analysis pipelines in GigaScience. We use these pipelines on a daily basis for data production and routine analysis and hope the community will find it [Read more]
Covid-19 updates at C3G We would like to provide a quick update amidst the coronavirus pandemic. While our host institutions (McGill University, SickKids Toronto) have put various measures in place to ensure the safety of our staff, our platform remains fully operational and available to support genomics research. Researchers [Read more]
