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2018
Caron, Maxime; St-Onge, Pascal; Drouin, Simon; Richer, Chantal; Sontag, Thomas; Busche, Stephan; Bourque, Guillaume; Pastinen, Tomi; Sinnett, Daniel
In: PLOS ONE, vol. 13, no. 11, pp. e0207250, 2018, ISSN: 1932-6203, (Publisher: Public Library of Science).
Abstract | Links | BibTeX | Tags: Blood, Cancers and neoplasms, Chromatin, DNA methylation, epigenetics, Histones, Human genomics, RNA sequencing
@article{caron_very_2018,
title = {Very long intergenic non-coding RNA transcripts and expression profiles are associated to specific childhood acute lymphoblastic leukemia subtypes},
author = {Maxime Caron and Pascal St-Onge and Simon Drouin and Chantal Richer and Thomas Sontag and Stephan Busche and Guillaume Bourque and Tomi Pastinen and Daniel Sinnett},
url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207250},
doi = {10.1371/journal.pone.0207250},
issn = {1932-6203},
year = {2018},
date = {2018-01-01},
urldate = {2021-05-19},
journal = {PLOS ONE},
volume = {13},
number = {11},
pages = {e0207250},
abstract = {Very long intergenic non-coding RNAs (vlincRNAs) are a novel class of long transcripts (textasciitilde50 kb to 1 Mb) with cell type- or cancer-specific expression. We report the discovery and characterization of 256 vlincRNAs from a cohort of 64 primary childhood pre-B and pre-T acute lymphoblastic leukemia (cALL) samples, of which 61% are novel and specifically expressed in cALL. Validation was performed in 35 pre-B and pre-T cALL primary samples. We show that their expression is cALL immunophenotype and molecular subtype-specific and correlated with epigenetic modifications on their promoters, much like protein-coding genes. While the biological functions of these vlincRNAs are still unknown, our results suggest they could play a role in cALL etiology or progression.},
note = {Publisher: Public Library of Science},
keywords = {Blood, Cancers and neoplasms, Chromatin, DNA methylation, epigenetics, Histones, Human genomics, RNA sequencing},
pubstate = {published},
tppubtype = {article}
}
Very long intergenic non-coding RNAs (vlincRNAs) are a novel class of long transcripts (textasciitilde50 kb to 1 Mb) with cell type- or cancer-specific expression. We report the discovery and characterization of 256 vlincRNAs from a cohort of 64 primary childhood pre-B and pre-T acute lymphoblastic leukemia (cALL) samples, of which 61% are novel and specifically expressed in cALL. Validation was performed in 35 pre-B and pre-T cALL primary samples. We show that their expression is cALL immunophenotype and molecular subtype-specific and correlated with epigenetic modifications on their promoters, much like protein-coding genes. While the biological functions of these vlincRNAs are still unknown, our results suggest they could play a role in cALL etiology or progression.