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2021

Sanchez-Ferras, Oraly; Pacis, Alain; Sotiropoulou, Maria; Zhang, Yuhong; Wang, Yu Chang; Bourgey, Mathieu; Bourque, Guillaume; Ragoussis, Jiannis; Bouchard, Maxime

A coordinated progression of progenitor cell states initiates urinary tract development Article de journal

Dans: Nature Communications, vol. 12, no. 1, p. 2627, 2021, ISSN: 2041-1723, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes: C3G, genomics, RNA-seq

Ward, Christopher M; Aumann, Roswitha A; Whitehead, Mark A; Nikolouli, Katerina; Leveque, Gary; Gouvi, Georgia; Fung, Elisabeth; Reiling, Sarah J; Djambazian, Haig; Hughes, Margaret A; Whiteford, Sam; Caceres-Barrios, Carlos; Nguyen, Thu N M; Choo, Amanda; Crisp, Peter; Sim, Sheina B; Geib, Scott M; Marec, František; Häcker, Irina; Ragoussis, Jiannis; Darby, Alistair C; Bourtzis, Kostas; Baxter, Simon W; Schetelig, Marc F

White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter Article de journal

Dans: Nature Communications, vol. 12, no. 1, p. 491, 2021, ISSN: 2041-1723, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Lee, Robert C; Farfan-Caceres, Lina; Debler, Johannes W; Williams, Angela H; Syme, Robert A; Henares, Bernadette M

Reference genome assembly for Australian Ascochyta lentis isolate Al4 Article de journal

Dans: G3 GenestextbarGenomestextbarGenetics, vol. 11, no. jkab006, 2021, ISSN: 2160-1836.

Résumé | Liens | BibTeX | Étiquettes:

Dursi, Jonathan L; Bozoky, Zoltan; de Borja, Richard; Li, Jimmy; Bujold, David; Lipski, Adam; Rashid, Shaikh Farhan; Sethi, Amanjeev; Memon, Neelam; Naidoo, Dashaylan; Coral-Sasso, Felipe; Wong, Matthew; Quirion, P -O; Lu, Zhibin; Agarwal, Samarth; Pavlov, Kat; Ponomarev, Andrew; Husic, Mia; Pace, Krista; Palmer, Samantha L; Grover, Stephanie A; Hakgor, Sevan; Siu, Lillian L; Malkin, David; Virtanen, Carl; Pugh, Trevor J; Jacques, Pierre-Étienne; Joly, Yann; Jones, Steven J M; Bourque, Guillaume; Brudno, Michael

CanDIG: Secure Federated Genomic Queries and Analyses Across Jurisdictions Article de journal

Dans: bioRxiv, p. 2021.03.30.434101, 2021, (Publisher: Cold Spring Harbor Laboratory Section: New Results).

Résumé | Liens | BibTeX | Étiquettes:

Lopez Leyva, Lilian; Gonzalez, Emmanuel; Li, Chen; Ajeeb, Tamara; Solomons, Noel W; Agellon, Luis B; Scott, Marilyn E; Koski, Kristine G

Human Milk Microbiota in an Indigenous Population Is Associated with Maternal Factors, Stage of Lactation, and Breastfeeding Practices Article de journal

Dans: Current Developments in Nutrition, vol. 5, no. nzab013, 2021, ISSN: 2475-2991.

Résumé | Liens | BibTeX | Étiquettes:

El-Far, Mohamed; Durand, Madeleine; Turcotte, Isabelle; Larouche-Anctil, Etienne; Sylla, Mohamed; Zaidan, Sarah; Chartrand-Lefebvre, Carl; Bunet, Rémi; Ramani, Hardik; Sadouni, Manel; Boldeanu, Irina; Chamberland, Annie; Lesage, Sylvie; Baril, Jean-Guy; Trottier, Benoit; Thomas, Réjean; Gonzalez, Emmanuel; Filali-Mouhim, Ali; Goulet, Jean-Philippe; Martinson, Jeffrey A; Kassaye, Seble; Karim, Roksana; Kizer, Jorge R; French, Audrey L; Gange, Stephen J; Ancuta, Petronela; Routy, Jean-Pierre; Hanna, David B; Kaplan, Robert C; Chomont, Nicolas; Landay, Alan L; Tremblay, Cécile L

Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis Article de journal

Dans: Frontiers in Immunology, vol. 12, 2021, ISSN: 1664-3224, (Publisher: Frontiers).

Résumé | Liens | BibTeX | Étiquettes: Atherosclerosis, CVD (cardio vascular disease), gut microbiome, HIV, IL-32, Inflammation, short-chain fatty acids

Brereton, N J B; Pitre, F E; Gonzalez, E

Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement Article de journal

Dans: Computational and Structural Biotechnology Journal, vol. 19, p. 2223–2235, 2021, ISSN: 2001-0370.

Résumé | Liens | BibTeX | Étiquettes: 16S rRNA gene, Astronaut health, Mars, Microbiome, Space science

2020

Chehboun, Salma; Leiva-Torres, Gabriel André; Charbonneau, Benoît; Eveleigh, Robert; Bourque, Guillaume; Vidal, Silvia Marina

A point mutation in the linker domain of mouse STAT5A is associated with impaired NK-cell regulation Article de journal

Dans: Genes & Immunity, vol. 21, no. 2, p. 136–141, 2020, ISSN: 1476-5470, (Number: 2 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Brereton, N J B; Gonzalez, E; Desjardins, D; Labrecque, M; Pitre, F E

Co-cropping with three phytoremediation crops influences rhizosphere microbiome community in contaminated soil Article de journal

Dans: Science of The Total Environment, vol. 711, p. 135067, 2020, ISSN: 0048-9697.

Résumé | Liens | BibTeX | Étiquettes: 16S rRNA, Co-cropping, Metagenomics, Microbiome, Phytoremediation, Rhizosphere

Nikbakht, Hamid; Jessa, Selin; Sukhai, Mahadeo A; Arseneault, Madeleine; Zhang, Tong; Letourneau, Louis; Thomas, Mariam; Bourgey, Mathieu; Roehrl, Michael H A; Eveleigh, Robert; Chen, Eric X; Krzyzanowska, Monika; Moore, Malcolm J; Giesler, Amanda; Yu, Celeste; Bedard, Philippe L; Kamel-Reid, Suzanne; Majewski, Jacek; Siu, Lillian L; Riazalhosseini, Yasser; Graham, Donna M

Latency and interval therapy affect the evolution in metastatic colorectal cancer Article de journal

Dans: Scientific Reports, vol. 10, no. 1, p. 581, 2020, ISSN: 2045-2322, (Number: 1 Publisher: Nature Publishing Group).

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Article de journal

Dans: 2020.

BibTeX | Étiquettes:

Lee, Robert C; Farfan-Caceres, Lina M; Debler, Johannes W; Syme, Robert A

Characterization of Growth Morphology and Pathology, and Draft Genome Sequencing of Botrytis fabae, the Causal Organism of Chocolate Spot of Faba Bean (Vicia faba L.) Article de journal

Dans: Frontiers in Microbiology, vol. 11, 2020, ISSN: 1664-302X, (Publisher: Frontiers).

Résumé | Liens | BibTeX | Étiquettes: ascomycete, BGM, botrytis fabae, chocolate spot, faba bean, Grey mould, Lens culinaris, Lentil, Necrotroph, phytopathogen, Plant Pathogen, Vicia faba

Morfin, Nuria; Goodwin, Paul H; Guzman-Novoa, Ernesto

Interaction of field realistic doses of clothianidin and Varroa destructor parasitism on adult honey bee (Apis mellifera L.) health and neural gene expression, and antagonistic effects on differentially expressed genes Article de journal

Dans: PLOS ONE, vol. 15, no. 2, p. e0229030, 2020, ISSN: 1932-6203, (Publisher: Public Library of Science).

Résumé | Liens | BibTeX | Étiquettes: Bees, Behavior, Gene expression, Honey bees, Insecticides, Invertebrate genomics, Mites, Parasitism

El-Sehemy, Ahmed; Selvadurai, Hayden; Ortin-Martinez, Arturo; Pokrajac, Neno; Mamatjan, Yasin; Tachibana, Nobuhiko; Rowland, Katherine; Lee, Lilian; Park, Nicole; Aldape, Kenneth; Dirks, Peter; Wallace, Valerie A

Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt Article de journal

Dans: The Journal of Clinical Investigation, vol. 130, no. 6, p. 3069–3086, 2020, ISSN: 0021-9738, (Publisher: American Society for Clinical Investigation).

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Moolhuijzen, Paula M; Muria-Gonzalez, Mariano Jordi; Syme, Robert; Rawlinson, Catherine; See, Pao Theen; Moffat, Caroline S; Ellwood, Simon R

Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp. Article de journal

Dans: Toxins, vol. 12, no. 4, p. 242, 2020, (Number: 4 Publisher: Multidisciplinary Digital Publishing Institute).

Résumé | Liens | BibTeX | Étiquettes: comparative genomics, necrotrophic fungal pathogen, NRPS, PKS, secondary metabolism, synteny

Choufani, Sanaa; Gibson, William T; Turinsky, Andrei L; Chung, Brian H Y; Wang, Tianren; Garg, Kopal; Vitriolo, Alessandro; Cohen, Ana S A; Cyrus, Sharri; Goodman, Sarah; Chater-Diehl, Eric; Brzezinski, Jack; Brudno, Michael; Ming, Luk Ho; White, Susan M; Lynch, Sally Ann; Clericuzio, Carol; Temple, Karen I; Flinter, Frances; McConnell, Vivienne; Cushing, Tom; Bird, Lynne M; Splitt, Miranda; Kerr, Bronwyn; Scherer, Stephen W; Machado, Jerry; Imagawa, Eri; Okamoto, Nobuhiko; Matsumoto, Naomichi; Testa, Guiseppe; Iascone, Maria; Tenconi, Romano; Caluseriu, Oana; Mendoza-Londono, Roberto; Chitayat, David; Cytrynbaum, Cheryl; Tatton-Brown, Katrina; Weksberg, Rosanna

DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes Article de journal

Dans: The American Journal of Human Genetics, vol. 106, no. 5, p. 596–610, 2020, ISSN: 0002-9297, 1537-6605, (Publisher: Elsevier).

Liens | BibTeX | Étiquettes: DNA methylation signature, EED, intellectual disability, overgrowth syndromes, SUZ12

Caron, Maxime; St-Onge, Pascal; Sontag, Thomas; Wang, Yu Chang; Richer, Chantal; Ragoussis, Ioannis; Sinnett, Daniel; Bourque, Guillaume

Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity Article de journal

Dans: Scientific Reports, vol. 10, no. 1, p. 8079, 2020, ISSN: 2045-2322, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Groza, Cristian; Kwan, Tony; Soranzo, Nicole; Pastinen, Tomi; Bourque, Guillaume

Personalized and graph genomes reveal missing signal in epigenomic data Article de journal

Dans: Genome Biology, vol. 21, no. 1, p. 124, 2020, ISSN: 1474-760X.

Résumé | Liens | BibTeX | Étiquettes: ChIP-seq, De novo assembly, Epigenomics, Genome graphs, Modified reference, Personalized genomes, Reference bias

Tremblay, Karine; Gaudet, Daniel; Khoury, Etienne; Brisson, Diane

Dissection of Clinical and Gene Expression Signatures of Familial versus Multifactorial Chylomicronemia Article de journal

Dans: Journal of the Endocrine Society, vol. 4, no. bvaa056, 2020, ISSN: 2472-1972.

Résumé | Liens | BibTeX | Étiquettes:

Zhuang, Qinwei Kim-Wee; Galvez, Jose Hector; Xiao, Qian; AlOgayil, Najla; Hyacinthe, Jeffrey; Taketo, Teruko; Bourque, Guillaume; Naumova, Anna K

Sex Chromosomes and Sex Phenotype Contribute to Biased DNA Methylation in Mouse Liver Article de journal

Dans: Cells, vol. 9, no. 6, p. 1436, 2020, (Number: 6 Publisher: Multidisciplinary Digital Publishing Institute).

Résumé | Liens | BibTeX | Étiquettes: DNA methylation, Gene expression, mouse liver, sex-chromosome complement, sexual dimorphism, whole genome bisulfite sequencing

Mohanraj, Suluxan; Díaz-Mejía, Javier J; Pham, Martin D; Elrick, Hillary; Husić, Mia; Rashid, Shaikh; Luo, Ping; Bal, Prabnur; Lu, Kevin; Patel, Samarth; Mahalanabis, Alaina; Naidas, Alaine; Christensen, Erik; Croucher, Danielle; Richards, Laura M; Shooshtari, Parisa; Brudno, Michael; Ramani, Arun K; Pugh, Trevor J

CReSCENT: CanceR Single Cell ExpressioN Toolkit Article de journal

Dans: Nucleic Acids Research, vol. 48, no. W1, p. W372–W379, 2020, ISSN: 0305-1048.

Résumé | Liens | BibTeX | Étiquettes:

Couturier, Charles P; Ayyadhury, Shamini; Le, Phuong U; Nadaf, Javad; Monlong, Jean; Riva, Gabriele; Allache, Redouane; Baig, Salma; Yan, Xiaohua; Bourgey, Mathieu; Lee, Changseok; Wang, Yu Chang David; Yong, V Wee; Guiot, Marie-Christine; Najafabadi, Hamed; Misic, Bratislav; Antel, Jack; Bourque, Guillaume; Ragoussis, Jiannis; Petrecca, Kevin

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy Article de journal

Dans: Nature Communications, vol. 11, no. 1, p. 3406, 2020, ISSN: 2041-1723, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Khazaei, Sima; Jay, Nicolas De; Deshmukh, Shriya; Hendrikse, Liam D; Jawhar, Wajih; Chen, Carol C L; Mikael, Leonie G; Faury, Damien; Marchione, Dylan M; Lanoix, Joel; Bonneil, Éric; Ishii, Takeaki; Jain, Siddhant U; Rossokhata, Kateryna; Sihota, Tianna S; Eveleigh, Robert; Lisi, Véronique; Harutyunyan, Ashot S; Jung, Sungmi; Karamchandani, Jason; Dickson, Brendan C; Turcotte, Robert; Wunder, Jay S; Thibault, Pierre; Lewis, Peter W; Garcia, Benjamin A; Mack, Stephen C; Taylor, Michael D; Garzia, Livia; Kleinman, Claudia L; Jabado, Nada

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Article de journal

Dans: Cancer Discovery, vol. 10, no. 12, p. 1968–1987, 2020, ISSN: 2159-8274, 2159-8290, (Publisher: American Association for Cancer Research Section: Research Articles).

Résumé | Liens | BibTeX | Étiquettes:

Wang, Yifan; Park, Jin Yong Patrick; Pacis, Alain; Denroche, Robert E; Jang, Gun Ho; Zhang, Amy; Cuggia, Adeline; Domecq, Celine; Monlong, Jean; Raitses-Gurevich, Maria; Grant, Robert C; Borgida, Ayelet; Holter, Spring; Stossel, Chani; Bu, Simeng; Masoomian, Mehdi; Lungu, Ilinca M; Bartlett, John M S; Wilson, Julie M; Gao, Zu-Hua; Riazalhosseini, Yasser; Asselah, Jamil; Bouganim, Nathaniel; Cabrera, Tatiana; Boucher, Louis-Martin; Valenti, David; Biagi, James; Greenwood, Celia M T; Polak, Paz; Foulkes, William D; Golan, Talia; O'Kane, Grainne M; Fischer, Sandra E; Knox, Jennifer J; Gallinger, Steven; Zogopoulos, George

A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer Article de journal

Dans: Clinical Cancer Research, vol. 26, no. 20, p. 5462–5476, 2020, ISSN: 1078-0432, 1557-3265, (Publisher: American Association for Cancer Research Section: Translational Cancer Mechanisms and Therapy).

Résumé | Liens | BibTeX | Étiquettes:

Moreau, Clara A; Urchs, Sebastian G W; Kuldeep, Kumar; Orban, Pierre; Schramm, Catherine; Dumas, Guillaume; Labbe, Aurélie; Huguet, Guillaume; Douard, Elise; Quirion, Pierre-Olivier; Lin, Amy; Kushan, Leila; Grot, Stephanie; Luck, David; Mendrek, Adrianna; Potvin, Stephane; Stip, Emmanuel; Bourgeron, Thomas; Evans, Alan C; Bearden, Carrie E; Bellec, Pierre; Jacquemont, Sebastien

Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia Article de journal

Dans: Nature Communications, vol. 11, no. 1, p. 5272, 2020, ISSN: 2041-1723, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

2019

Robert Eveleigh, Guillaume Bourque

A point mutation in the linker domain of mouse STAT5A is associated with impaired NK-cell regulation Article de journal

Dans: 2019.

Résumé | Liens | BibTeX | Étiquettes: Immunogenetics, Innate immune cells

Ana S. Guerreiro Stucklin, Scott Ryall

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas Article de journal

Dans: 2019.

Résumé | Liens | BibTeX | Étiquettes: Cancer genomics, Molecular medicine

Turinsky, Andrei L; Butcher, Darci T; Choufani, Sanaa; Weksberg, Rosanna; Brudno, Michael

Don’t brush off buccal data heterogeneity Article de journal

Dans: Epigenetics, vol. 14, no. 2, p. 109-117, 2019, (PMID: 30821575).

Liens | BibTeX | Étiquettes:

Page, Donna J; Miossec, Matthieu J; Williams, Simon G; Monaghan, Richard M; Fotiou, Elisavet; Cordell, Heather J; Sutcliffe, Louise; Topf, Ana; Bourgey, Mathieu; Bourque, Guillaume; Eveleigh, Robert; Dunwoodie, Sally L; Winlaw, David S; Bhattacharya, Shoumo; Breckpot, Jeroen; Devriendt, Koenraad; Gewillig, Marc; Brook, David J; Setchfield, Kerry J; Bu’Lock, Frances A; O’Sullivan, John; Stuart, Graham; Bezzina, Connie R; Mulder, Barbara J M; Postma, Alex V; Bentham, James R; Baron, Martin; Bhaskar, Sanjeev S; Black, Graeme C; Newman, William G; Hentges, Kathryn E; Lathrop, Mark G; Santibanez-Koref, Mauro; Keavney, Bernard D

Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot Article de journal

Dans: Circulation Research, vol. 124, no. 4, p. 553-563, 2019.

Liens | BibTeX | Étiquettes:

Laperle, Jonathan; Hébert-Deschamps, Simon; Raby, Joanny; de Lima Morais, David A; Barrette, Michel; Bujold, David; Bastin, Charlotte; Robert, Marc-Antoine; Nadeau, Jean-François; Harel, Marie; Nordell-Markovits, Alexei; Veilleux, Alain; Bourque, Guillaume; Jacques, Pierre-Étienne

The epiGenomic Efficient Correlator (epiGeEC) tool allows fast comparison of user datasets with thousands of public epigenomic datasets Article de journal

Dans: Bioinformatics, vol. 35, no. 4, p. 674–676, 2019, ISSN: 1367-4803.

Résumé | Liens | BibTeX | Étiquettes:

Shokoohi, Farhad; Stephens, David A; Bourque, Guillaume; Pastinen, Tomi; Greenwood, Celia M T; Labbe, Aurélie

A hidden markov model for identifying differentially methylated sites in bisulfite sequencing data Article de journal

Dans: Biometrics, vol. 75, no. 1, p. 210–221, 2019, ISSN: 1541-0420, (_eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/biom.12965).

Résumé | Liens | BibTeX | Étiquettes: Blood cell-separated data, Differentially methylated region, Next-generation sequencing, Read-depth

Choufani, Sanaa; Turinsky, Andrei L; Melamed, Nir; Greenblatt, Ellen; Brudno, Michael; Bérard, Anick; Fraser, William D; Weksberg, Rosanna; Trasler, Jacquetta; Monnier, Patricia; cohort study group, 3D

Impact of assisted reproduction, infertility, sex and paternal factors on the placental DNA methylome Article de journal

Dans: Human Molecular Genetics, vol. 28, no. 3, p. 372–385, 2019, ISSN: 0964-6906.

Résumé | Liens | BibTeX | Étiquettes:

Cvetkovska, Marina; Orgnero, Shane; Hüner, Norman P A; Smith, David Roy

The enigmatic loss of light-independent chlorophyll biosynthesis from an Antarctic green alga in a light-limited environment Article de journal

Dans: New Phytologist, vol. 222, no. 2, p. 651–656, 2019, ISSN: 1469-8137, (_eprint: https://nph.onlinelibrary.wiley.com/doi/pdf/10.1111/nph.15623).

Liens | BibTeX | Étiquettes: Chlamydomonas sp. UWO241, chlorophyll, DPOR, photosynthesis, psychrophile

Article de journal

Dans: Epigenetics, vol. 14, no. 2, p. 109–117, 2019.

BibTeX | Étiquettes: buccal epithelial cells, DNA methylation, epigenetics, tissue heterogeneity

Untereiner, Ashley; Abdo, Shaaban; Bhattacharjee, Alpana; Gohil, Himaben; Pourasgari, Farzaneh; Ibeh, Neke; Lai, Mi; Batchuluun, Battsetseg; Wong, Anthony; Khuu, Nicholas; Liu, Ying; Rijjal, Dana Al; Winegarden, Neil; Virtanen, Carl; Orser, Beverley A; Cabrera, Over; Varga, Gabor; Rocheleau, Jonathan; Dai, Feihan F; Wheeler, Michael B

GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity Article de journal

Dans: The FASEB Journal, vol. 33, no. 3, p. 3968–3984, 2019, ISSN: 1530-6860, (_eprint: https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201801397R).

Résumé | Liens | BibTeX | Étiquettes: diet-induced obesity, GABAA receptor, glucose tolerance, insulin secretion, single cell RNA-seq

Sukhai, Mahadeo A; Misyura, Maksym; Thomas, Mariam; Garg, Swati; Zhang, Tong; Stickle, Natalie; Virtanen, Carl; Bedard, Philippe L; Siu, Lillian L; Smets, Tina; Thijs, Gert; Vooren, Steven Van; Kamel-Reid, Suzanne; Stockley, Tracy L

Somatic Tumor Variant Filtration Strategies to Optimize Tumor-Only Molecular Profiling Using Targeted Next-Generation Sequencing Panels Article de journal

Dans: The Journal of Molecular Diagnostics, vol. 21, no. 2, p. 261–273, 2019, ISSN: 1525-1578, (Publisher: Elsevier).

Résumé | Liens | BibTeX | Étiquettes:

Gonorazky, Hernan D; Naumenko, Sergey; Ramani, Arun K; Nelakuditi, Viswateja; Mashouri, Pouria; Wang, Peiqui; Kao, Dennis; Ohri, Krish; Viththiyapaskaran, Senthuri; Tarnopolsky, Mark A; Mathews, Katherine D; Moore, Steven A; Osorio, Andres N; Villanova, David; Kemaladewi, Dwi U; Cohn, Ronald D; Brudno, Michael; Dowling, James J

Expanding the Boundaries of RNA Sequencing as a Diagnostic Tool for Rare Mendelian Disease Article de journal

Dans: The American Journal of Human Genetics, vol. 104, no. 3, p. 466–483, 2019, ISSN: 0002-9297, 1537-6605, (Publisher: Elsevier).

Liens | BibTeX | Étiquettes: diagnostics, Mendelian disease, muscular dystrophy, myotubes, RNA-seq, Transcriptomics, transdifferentiation

Chong, Jasmine; Yamamoto, Mai; Xia, Jianguo

MetaboAnalystR 2.0: From Raw Spectra to Biological Insights Article de journal

Dans: Metabolites, vol. 9, no. 3, p. 57, 2019, (Number: 3 Publisher: Multidisciplinary Digital Publishing Institute).

Résumé | Liens | BibTeX | Étiquettes: enrichment analysis, global metabolomics, LC-MS, pathway analysis, spectra processing

Zhou, Guangyan; Soufan, Othman; Ewald, Jessica; Hancock, Robert E W; Basu, Niladri; Xia, Jianguo

NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis Article de journal

Dans: Nucleic Acids Research, vol. 47, no. W1, p. W234–W241, 2019, ISSN: 0305-1048.

Résumé | Liens | BibTeX | Étiquettes:

Gonzalez, Emmanuel; Pitre, Frederic E; Brereton, Nicholas J B

ANCHOR: a 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples Article de journal

Dans: Environmental Microbiology, vol. 21, no. 7, p. 2440–2468, 2019, ISSN: 1462-2920, (_eprint: https://sfamjournals.onlinelibrary.wiley.com/doi/pdf/10.1111/1462-2920.14632).

Résumé | Liens | BibTeX | Étiquettes:

Breeze, Charles E; Reynolds, Alex P; van Dongen, Jenny; Dunham, Ian; Lazar, John; Neph, Shane; Vierstra, Jeff; Bourque, Guillaume; Teschendorff, Andrew E; Stamatoyannopoulos, John A; Beck, Stephan

eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data Article de journal

Dans: Bioinformatics, vol. 35, no. 22, p. 4767–4769, 2019, ISSN: 1367-4803.

Résumé | Liens | BibTeX | Étiquettes:

Bourgey, Mathieu; Dali, Rola; Eveleigh, Robert; Chen, Kuang Chung; Letourneau, Louis; Fillon, Joel; Michaud, Marc; Caron, Maxime; Sandoval, Johanna; Lefebvre, Francois; Leveque, Gary; Mercier, Eloi; Bujold, David; Marquis, Pascale; Van, Patrick Tran; Anderson de Lima Morais, David; Tremblay, Julien; Shao, Xiaojian; Henrion, Edouard; Gonzalez, Emmanuel; Quirion, Pierre-Olivier; Caron, Bryan; Bourque, Guillaume

GenPipes: an open-source framework for distributed and scalable genomic analyses Article de journal

Dans: GigaScience, vol. 8, no. giz037, 2019, ISSN: 2047-217X.

Résumé | Liens | BibTeX | Étiquettes:

Morou, Antigoni; Brunet-Ratnasingham, Elsa; Dubé, Mathieu; Charlebois, Roxanne; Mercier, Eloi; Darko, Sam; Brassard, Nathalie; Nganou-Makamdop, Krystelle; Arumugam, Sahaana; Gendron-Lepage, Gabrielle; Yang, Lifei; Niessl, Julia; Baxter, Amy E; Billingsley, James M; Rajakumar, Premeela A; Lefebvre, François; Johnson, Paul R; Tremblay, Cécile; Routy, Jean-Pierre; Wyatt, Richard T; Finzi, Andrés; Douek, Daniel C; Kaufmann, Daniel E

Altered differentiation is central to HIV-specific CD4 + Ŧ cell dysfunction in progressive disease Article de journal

Dans: Nature Immunology, vol. 20, no. 8, p. 1059–1070, 2019, ISSN: 1529-2916, (Number: 8 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Siu, M T; Butcher, D T; Turinsky, A L; Cytrynbaum, C; Stavropoulos, D J; Walker, S; Caluseriu, O; Carter, M; Lou, Y; Nicolson, R; Georgiades, S; Szatmari, P; Anagnostou, E; Scherer, S W; Choufani, S; Brudno, M; Weksberg, R

Functional DNA methylation signatures for autism spectrum disorder genomic risk loci: 16p11.2 deletions and CHD8 variants Article de journal

Dans: Clinical Epigenetics, vol. 11, no. 1, p. 103, 2019, ISSN: 1868-7083.

Résumé | Liens | BibTeX | Étiquettes: Autism spectrum disorder, DNA methylation, epigenetics, Genetic stratification, Genomic variants, Heterogeneity

Chang, Matthew L; Moussette, Sanny; Gamero-Estevez, Enrique; Gálvez, José Héctor; Chiwara, Victoria; Gupta, Indra R; Ryan, Aimee K; Naumova, Anna K

Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock Article de journal

Dans: PLOS ONE, vol. 14, no. 9, p. e0223212, 2019, ISSN: 1932-6203, (Publisher: Public Library of Science).

Résumé | Liens | BibTeX | Étiquettes: Asthma, Circadian oscillators, Circadian rhythms, Gene expression, Gene regulation, Genetic oscillators, Ileum, Transcriptional control

Grajcarek, Janin; Monlong, Jean; Nishinaka-Arai, Yoko; Nakamura, Michiko; Nagai, Miki; Matsuo, Shiori; Lougheed, David; Sakurai, Hidetoshi; Saito, Megumu K; Bourque, Guillaume; Woltjen, Knut

Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Article de journal

Dans: Nature Communications, vol. 10, no. 1, p. 4856, 2019, ISSN: 2041-1723, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Minerbi, Amir; Gonzalez, Emmanuel; Brereton, Nicholas J B; Anjarkouchian, Abraham; Dewar, Ken; Fitzcharles, Mary-Ann; Chevalier, Stéphanie; Shir, Yoram

Altered microbiome composition in individuals with fibromyalgia Article de journal

Dans: PAIN, vol. 160, no. 11, p. 2589–2602, 2019, ISSN: 0304-3959.

Résumé | Liens | BibTeX | Étiquettes:

Jessa, Selin; Blanchet-Cohen, Alexis; Krug, Brian; Vladoiu, Maria; Coutelier, Marie; Faury, Damien; Poreau, Brice; Jay, Nicolas De; Hébert, Steven; Monlong, Jean; Farmer, Todd W; Donovan, Laura K; Hu, Yixing; McConechy, Melissa K; Cavalli, Florence M G; Mikael, Leonie G; Ellezam, Benjamin; Richer, Maxime; Allaire, Andréa; Weil, Alexander G; Atkinson, Jeffrey; Farmer, Jean-Pierre; Dudley, Roy W R; Larouche, Valerie; Crevier, Louis; Albrecht, Steffen; Filbin, Mariella G; Sartelet, Hervé; Lutz, Pierre-Eric; Nagy, Corina; Turecki, Gustavo; Costantino, Santiago; Dirks, Peter B; Murai, Keith K; Bourque, Guillaume; Ragoussis, Jiannis; Garzia, Livia; Taylor, Michael D; Jabado, Nada; Kleinman, Claudia L

Stalled developmental programs at the root of pediatric brain tumors Article de journal

Dans: Nature Genetics, vol. 51, no. 12, p. 1702–1713, 2019, ISSN: 1546-1718, (Number: 12 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Saulnier, Katie M; Bujold, David; Dyke, Stephanie O M; Dupras, Charles; Beck, Stephan; Bourque, Guillaume; Joly, Yann

Benefits and barriers in the design of harmonized access agreements for international data sharing Article de journal

Dans: Scientific Data, vol. 6, no. 1, p. 297, 2019, ISSN: 2052-4463, (Number: 1 Publisher: Nature Publishing Group).

Résumé | Liens | BibTeX | Étiquettes:

Sengar, Ameet S; Li, Hongbin; Zhang, Wenbo; Leung, Celeste; Ramani, Arun K; Saw, Ner Mu; Wang, Yongqian; Tu, YuShan; Ross, Joel P; Scherer, Stephen W; Ellis, James; Brudno, Michael; Jia, Zhengping; Salter, Michael W

Control of Long-Term Synaptic Potentiation and Learning by Alternative Splicing of the NMDA Receptor Subunit GluN1 Article de journal

Dans: Cell Reports, vol. 29, no. 13, p. 4285–4294.e5, 2019, ISSN: 2211-1247, (Publisher: Elsevier).

Liens | BibTeX | Étiquettes: autism, GluN1, long-term potentiation, N1 cassette, NMDA Receptor, splicing

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