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2017
Bourguinat, Catherine; Lefebvre, Francois; Sandoval, Johanna; Bondesen, Brenda; Moreno, Yovany; Prichard, Roger K
Dirofilaria immitis JYD-34 isolate: whole genome analysis Journal Article
In: Parasites & Vectors, vol. 10, no. 2, pp. 494, 2017, ISSN: 1756-3305.
Abstract | Links | BibTeX | Tags: Dirofilaria immitis, Heartworm preventives, JYD isolate, Macrocyclic lactone resistance, Whole genome analysis
@article{bourguinat_dirofilaria_2017,
title = {Dirofilaria immitis JYD-34 isolate: whole genome analysis},
author = {Catherine Bourguinat and Francois Lefebvre and Johanna Sandoval and Brenda Bondesen and Yovany Moreno and Roger K Prichard},
url = {https://doi.org/10.1186/s13071-017-2437-5},
doi = {10.1186/s13071-017-2437-5},
issn = {1756-3305},
year = {2017},
date = {2017-01-01},
urldate = {2021-05-19},
journal = {Parasites & Vectors},
volume = {10},
number = {2},
pages = {494},
abstract = {Macrocyclic lactone (ML) anthelmintics are used for chemoprophylaxis for heartworm infection in dogs and cats. Cases of dogs becoming infected with heartworms, despite apparent compliance to recommended chemoprophylaxis with approved preventives, has led to such cases being considered as suspected lack of efficacy (LOE). Recently, microfilariae collected from a small number of LOE isolates were used as a source of infection of new host dogs and confirmed to have reduced susceptibility to ML in controlled efficacy studies using L3 challenge in dogs. A specific Dirofilaria immitis laboratory isolate named JYD-34 has also been confirmed to have less than 100% susceptibility to ML-based preventives. For preventive claims against heartworm disease, evidence of 100% efficacy is required by FDA-CVM. It was therefore of interest to determine whether JYD-34 has a genetic profile similar to other documented LOE and confirmed reduced susceptibility isolates or has a genetic profile similar to known ML-susceptible isolates.},
keywords = {Dirofilaria immitis, Heartworm preventives, JYD isolate, Macrocyclic lactone resistance, Whole genome analysis},
pubstate = {published},
tppubtype = {article}
}
Macrocyclic lactone (ML) anthelmintics are used for chemoprophylaxis for heartworm infection in dogs and cats. Cases of dogs becoming infected with heartworms, despite apparent compliance to recommended chemoprophylaxis with approved preventives, has led to such cases being considered as suspected lack of efficacy (LOE). Recently, microfilariae collected from a small number of LOE isolates were used as a source of infection of new host dogs and confirmed to have reduced susceptibility to ML in controlled efficacy studies using L3 challenge in dogs. A specific Dirofilaria immitis laboratory isolate named JYD-34 has also been confirmed to have less than 100% susceptibility to ML-based preventives. For preventive claims against heartworm disease, evidence of 100% efficacy is required by FDA-CVM. It was therefore of interest to determine whether JYD-34 has a genetic profile similar to other documented LOE and confirmed reduced susceptibility isolates or has a genetic profile similar to known ML-susceptible isolates.