Monthly Archives: December 2021

A small number of early introductions seeded widespread transmission of SARS-CoV-2 in Quebec, Canada

A small number of early introductions seeded widespread transmission of SARS-CoV-2 in Quebec, Canada In April 2020, the Coronavirus Sequencing in Québec (CoVSeQ) consortium was assembled to sequence SARS-CoV-2 genomes in Québec to track viral introduction events and transmission within the province. Jose Hector Galvez, Pierre-Olivier Quirion, Paul Stretenowich, [Read more]

Platforms to help identify asymptomatic carriers of COVID-19

Platforms to help identify asymptomatic carriers of COVID-19 Identifying asymptomatic carriers of the novel coronavirus is crucial in preventing the spread of COVID-19, particularly in healthcare settings. C3G’s Toronto Node has developed several applications for this purpose across various health institutions. The Mt. Sinai Hospital and Lunenfeld-Tanenbaum Research Institute’s Stay-Healthy-At-Work [Read more]

Understanding why persons living with HIV are at increased risk of tuberculosis

Understanding why persons living with HIV are at increased risk of tuberculosis Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB).  HIV-associated TB is often the result of a recent infection with Mycobacterium tuberculosis (Mtb) followed by rapid progression to the disease. Alveolar macrophages (AM) are the first cells [Read more]

STOP-CoV: Examining COVID-19 vaccination responses across age groups

STOP-CoV: Examining COVID-19 vaccination responses across age groups As the rollout for COVID-19 vaccinations continues across Ontario the C3G Toronto Node has helped establish STOP-CoV (SafeTy and Efficacy of Preventative COVID Vaccines), a province-wide study to examine the differences in COVID-19 vaccine responses between younger and older individuals. Participants contribute to the study by completing a [Read more]

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19 Host genetic factors related to COVID-19 susceptibility and outcomes are of great interest, as their identification could elucidate the mechanisms of SARS-CoV-2 infection and severity, thereby providing clues about potential therapeutic targets. A recent [Read more]

A Coordinated Progression of Progenitor Cell States Initiates Urinary Tract Development

A Coordinated Progression of Progenitor Cell States Initiates Urinary Tract Development Oraly Sanchez-Ferras from the Goodman Cancer Research Centre recently published a paper in Nature Communications. She reveals how the formation of tissues proceeds through a progression of different progenitors. This understanding is important for the generation of organ [Read more]

Whole Genome STR Analysis

Whole Genome STR Analysis By David Lougheed About Short Tandem Repeats In early 2021, Jeffrey Hyacinthe, another student here in Guillaume Bourque’s lab, wrote about repetitive sequences, focusing on transposable elements (TEs). Here I will discuss another type of repetitive sequence: short tandem repeats (STRs), also known as microsatellites. These [Read more]

New study analyzes different mechanisms in the establishment of sex-phenotype dependent methylation in mouse livers

New study analyzes different mechanisms in the establishment of sex-phenotype dependent methylation in mouse livers By Hector Galvez and Qinwei Zhuang AlOgayil, N., Bauermeister, K., Galvez, J.H. et al. Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver. [Read more]

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