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STOP-CoV: Examining COVID-19 vaccination responses across age groups

STOP-CoV: Examining COVID-19 vaccination responses across age groups As the rollout for COVID-19 vaccinations continues across Ontario the C3G Toronto Node has helped establish STOP-CoV (SafeTy and Efficacy of Preventative COVID Vaccines), a province-wide study to examine the differences in COVID-19 vaccine responses between younger and older individuals. Participants contribute to the study by completing a [Read more]

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19 Host genetic factors related to COVID-19 susceptibility and outcomes are of great interest, as their identification could elucidate the mechanisms of SARS-CoV-2 infection and severity, thereby providing clues about potential therapeutic targets. A recent [Read more]

A Coordinated Progression of Progenitor Cell States Initiates Urinary Tract Development

A Coordinated Progression of Progenitor Cell States Initiates Urinary Tract Development Oraly Sanchez-Ferras from the Goodman Cancer Research Centre recently published a paper in Nature Communications. She reveals how the formation of tissues proceeds through a progression of different progenitors. This understanding is important for the generation of organ [Read more]

Whole Genome STR Analysis

Whole Genome STR Analysis By David Lougheed About Short Tandem Repeats In early 2021, Jeffrey Hyacinthe, another student here in Guillaume Bourque’s lab, wrote about repetitive sequences, focusing on transposable elements (TEs). Here I will discuss another type of repetitive sequence: short tandem repeats (STRs), also known as microsatellites. These [Read more]

New study analyzes different mechanisms in the establishment of sex-phenotype dependent methylation in mouse livers

New study analyzes different mechanisms in the establishment of sex-phenotype dependent methylation in mouse livers By Hector Galvez and Qinwei Zhuang AlOgayil, N., Bauermeister, K., Galvez, J.H. et al. Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver. [Read more]

McGill researchers awarded Azrieli Science Grant for RNA and the brain

McGill researchers awarded Azrieli Science Grant for RNA and the brain Dr. Wayne Sossin, Professor at The Montreal Neurological Institute, McGill University, Montreal, has been awarded a grant through the Azrieli Science Grants Program as principal investigator for a research project titled “Determining how stalled polysomes are generated for [Read more]

Astronaut gut microbiome alterations induced by long-duration confinement

Astronaut gut microbiome alterations induced by long-duration confinement Throughout long-duration spaceflight, maintaining astronaut health is crucial to the feasibility of a manned mission to Mars. In the longest controlled human confinement study conducted to date, the ground-based Mars500 experiment investigated long-duration health by isolating six astronauts for 520 days. [Read more]

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