Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease
Another noteworthy publication to which C3G members contributed as authors was published in Nature Immunology this summer. An important focus of the study was the comparison of HIV-specific CD4 T-cells subpopulations from patients who have undergone antiretroviral therapy and patients who spontaneously suppress HIV viral load below detectable limits (a.k.a. elite controller patients). This comparison contributes to an understanding of why viral control is lost once antiretrovial activity therapy is interrupted.